Automated antigen assays display a high heterogeneity for the detection of SARS-CoV-2 variants of concern, including several Omicron sublineages.

"Declarations Conflicts of interestThe authors declare that they have no conflict of interest. Ethics approvalFor sensitivity testing, ethical approval was not required, because all patient samples used were residual samples. Samples were identified in the laboratory and assigned a number without reference to patient or clinical details. The data of the specificity testing were obtained from anonymized results of a previous study in which assays from residual material were used for this purpose. Therefore, the results from anonymized testing did not impact on clinical care and did not require an ethics statement. Conflicts of interest The authors declare that they have no conflict of interest."

"Funding Open Access funding enabled and organized by Projekt DEAL. This work was supported by the Free State of Bavaria through research initiatives Bay-VOC (M.M., A.G., S.K., H.B., U.P., O.T.K.) and FOR-COVID (M.M., U.P., O.T.K.)."