Safety of Supplementation of Omega-3 Polyunsaturated Fatty Acids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

"Conflict of interest The authors report no conflicts of interest."

"Funding The authors of this work were supported by the following grants: MOST 109-2320-B-038-057-MY3, 110-2321-B-006-004, 110-2811-B-039-507, 110-2320-B-039-048-MY2,110-2320-B-039-047-MY3, 110-2813-C-039-327-B, 110-2314-B-039-029-MY3, 111-2321-B-006-008, and NSTC 111-2314-B-039-041-MY3 from the National Science and Technology Council, Taiwan; ANHRF 109-31, 109-40, 110-13, 110-26, 110-44, 110-45, 111-27, 111-28, 111-47, 111-48, and 111-52 from An-Nan Hospital, China Medical University, Tainan, Taiwan; CMRC-CMA-2 from Higher Education Sprout Project by the Ministry of Education (MOE), Taiwan; CMU 110-AWARD-02, 110-N-17, 1110-SR-73 from the China Medical University, Taichung, Taiwan; and DMR-106-101, 106-227, 109-102, 109-244, 110-124, 111-245, 112-097, 112-086, 112-109, 112-232 and DMR-HHC-109-11, HHC-109-12, HHC-110-10, and HHC-111-8 from the China Medical University Hospital, Taichung, Taiwan.; and Grant VGHKS107-075 from Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan."

"The present study followed the PRISMA guidelines [] (). The current meta-analysis fulfilled the certification requirements of the Institutional Review Board of the Kaohsiung Veterans General Hospital (approval # VGHKS17-EM10-01) and has been registered in PROSPERO (CRD42023401169).FIGURE 1Flow chart of current meta-analysis.FIGURE 1 This study was registered at PROSPERO as CRD42023401169."