PPARδ dysregulation of CCL20/CCR6 axis promotes gastric adenocarcinoma carcinogenesis by remodeling gastric tumor microenvironment.

"Declarations Conflict of interestThe authors declare that they have no conflicts of interest. Ethical approvalThe animal study was approved by the Institutional Animal Care and Use Committee of The University of Texas MD Anderson Cancer Center (IACUC #001315). All institutional and national guidelines for the care and use of laboratory animals were followed. Conflict of interest The authors declare that they have no conflicts of interest."

"This work was supported by the National Cancer Institute grants (R01CA236905 and R03CA235106 to X. Z; R01CA142969 and R01CA266223 to I.S.); the Cancer Prevention and Research Institute of Texas grants (RP140224 to I.S.); the University of Texas MD Anderson internal research grant (PS103703 to X.Z); Texas Medical Center Digestive Diseases Center seed grant (Record#: AWD00005436 by sponsor award 5P30DK056338-18 to X.Z); the University of Texas MD Anderson Cancer Center Duncan Family Institute for Cancer Prevention and Risk Assessment (#123264 to D.W. ), and the University of Texas MD Anderson Cancer Center Institutional Research Program (#125092 to D.W). This study made use of the MD Anderson Cancer Center Genetically Engineered Mouse Facility and Flow Cytometry and Cellular Imaging Facility and was supported by Cancer Center Support Grant P30CA016672. The manuscript was edited by Sarah Bronson, ELS, of the Research Medical Library at The University of Texas MD Anderson Cancer Center."