Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer therapy strategy.

"Declaration of competing interest Jiuming He, Yan Li, Jin Zhang, Qianqian Du and Hongtao Jin are inventors of an awarded patent application (201910162557.8) submitted by Institute of Materia Medica, Chinese Academy of Medical Sciences that related to choline- or betaine-modified taxanes. All other authors declare that they have no conflicts of interest."

"We thank Peking Union Medical College Hospital for providing clinical lung cancer tissue samples after surgery. We also would like to thank Beijing Union-Genius Pharmaceutical Technology Development Co., Ltd. for performing toxicity experiment and BioDuro Shanghai Co., Ltd. for synthesis of modified taxane compounds. This work was supported by the National Natural Science Foundation of China (Grant Nos.: 81974500 and 81773678), and the CAMS Innovation Fund for Medical Sciences (Grant No.: 2022-I2M-2-001). Xiangyi Wang and Jin Zhang: Methodology, Investigation, Formal analysis, Visualization, Writing - Original draft preparation; Kailu Zheng and Qianqian Du: Investigation, Formal analysis, Visualization; Guocai Wang: Investigation, Validation; Jianpeng Huang: Project administration, Resources, Data curation; Yanhe Zhou: Investigation, Validation; Yan Li: Conceptualization, Methodology, Supervision, Writing - Reviewing and Editing; Hongtao Jin: Project administration, Resources, Data curation; Jiuming He: Conceptualization, Methodology, Supervision, Writing - Reviewing and Editing, Funding acquisition."