The neuropathological mechanism of EV-A71 infection attributes to inflammatory pryoptosis and viral replication via activating the hsa_circ_0045431/ hsa_miR_584/NLRP3 regulatory axis.

"Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"The present study was supported by funding from the National Natural Sciences Foundations of China (32000128), CAMS Innovation Fund for Medical Sciences (2021-I2M-1–043), 10.13039/501100005147Yunnan Applied Basic Research Projects (2019FB018, 202101AT070227 and 202201AT070237), Medical Reserve Talents of Yunnan Province Health and Family Planning (H-2019061), Kunming Medical University Joint special Project (202201AY070001–252), 10.13039/501100018576Top young talents of Yunnan province ten thousand talents plan (YNWR-QNBJ-2019–143 and XDYC-QNRC-2022–0300), Workstation of Academician Zhong Nanshan (202305AF150147) and Respiratory Diseases Clinical Medical Research Center of Yunnan Province (202102AA100057). Yajie Hu: Conceptualization, Writing – original draft, Funding acquisition. Yue Yu: Methodology, Data curation. Ruian Yang: Software, Data curation. Ruibing Wang: Methodology, Software. Dandan Pu: Methodology. Yujue Wang: Visualization, Investigation. Jingyuan Fan: Software, Investigation. Yunhui Zhang: Conceptualization, Supervision, Writing – review & editing. Jie Song: Conceptualization, Writing – review & editing, Funding acquisition."