Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis.

"individual-level processed rna-seq data and 5hmc-seal data have been deposited into the ncbi gene expression omnibus database (gse196533)."

"Declarations Ethics approval and consent to participateThis study was performed under a protocol that was approved by the Institutional Review Board (IRB) of Northwestern University Feinberg School of Medicine. Competing interestsWZ was an advisor and shareholder of Epican Technology, Ltd., which held a license of the 5hmC-Seal technology from the University of Chicago for clinical applications. The other authors declare that they have no competing interests. Competing interests WZ was an advisor and shareholder of Epican Technology, Ltd., which held a license of the 5hmC-Seal technology from the University of Chicago for clinical applications. The other authors declare that they have no competing interests."

"Funding This study was supported, in part, by grants from the National Institutes of Health—CA209345 (Zhang & Cheng), NS115403 (Cheng) and CA221747 (Cheng), the Phi Beta Psi Sorority (Zhang), and the Lou and Jean Malnati Brain Tumor Institute at Northwestern University (Zhang & Cheng). The Northwestern NSTB is part of the Biospecimen Core supported by NCI P50CA221747 (Horbinski)."