Gastrointestinal Delivery of an mRNA Vaccine Using Immunostimulatory Polymeric Nanoparticles.

Authors:
Kim H; Kirtane AR; Kim NY; Rajesh NU; Tang C and 4 more

Journal:
AAPS J

Publication Year: 2023

DOI:
10.1208/s12248-023-00844-z

PMCID:
PMC10845796

PMID:
37589795

Journal Information

Full Title: AAPS J

Abbreviation: AAPS J

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Drug Therapy

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
3/6
50.0% Transparent
Transparency Indicators
Click on green indicators to view evidence text
Core Indicators
Data Sharing
Code Sharing
Evidence found in paper:

"Conflict of Interest R.L. is a co-founder and serves on the board of directors of Moderna Therapeutics. Complete details of all relationships for profit and not for profit for G.T. and R.L. can be found at the following link: https://www.dropbox.com/sh/szi7vnr4a2ajb56/AABs5N5i0q9AfT1IqIJAE-T5a?dl=0, and https://www.dropbox.com/s/yc3xqb5s8s94v7x/Rev%20Langer%20COI.pdf?dl=0, respectively. GT, RL, HK, NR and ARK are co-inventors on US patent application 17/689,314 that describes the use of poly(beta amino ester) polymers for the delivery of nucleic acid to the GI tract. The authors declare no other competing interests."

Evidence found in paper:

"Funding ‘Open Access funding provided by the MIT Libraries’ This study was funded in part by the Karl van Tassel (1925) Career Development Professorship and the Department of Mechanical Engineering, MIT (G.T.), National Institutes of Health P20 GM103638 (H.K.), and PhRMA Foundation Fellowship (A.K.)."

Protocol Registration
Open Access
Paper is freely available to read
Additional Indicators
Replication
Novelty Statement
Assessment Info

Tool: rtransparent

OST Version: N/A

Last Updated: Aug 05, 2025