Efficacy and Safety of Hybrid Comprehensive Telerehabilitation (HCTR) for Cardiac Rehabilitation in Patients with Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

"Conflicts of Interest The authors declared no potential conflicts of interest with respect to the research, authorship, and publication of this article."

"This work was supported by the National Natural Science Foundation of China (32071116, 82070300, and 82270300) and Natural Science Foundation of Liaoning Province of China (2022JH2/101500028, 2022JH2/101300012). We are grateful to all the researchers involved in this study."

" Our findings indicate that HCTR is as effective as traditional rehabilitation care in reducing readmission rates and mortality and improving quality of life in patients with CVD. However, HCTR offers the added advantage of improving VO 2 peak and 6MWT, measurements of cardiorespiratory fitness and functional capacity, respectively. These results suggest that HCTR can be a safe and effective alternative to traditional rehabilitation care, offering numerous benefits for CVD patients. Clinical Study Registration Number. This trial is registered with NCT02523560 and NCT02796404 ."