Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to App^NL-G-F knock-in Alzheimer mice.

"Declarations Ethics approval and consent to participateAll animal experiments were carried out under the ethical permits ID 407 approved by Linköping animal ethical board, 12570–2021 and 5406–2020 approved by Stockholm animal ethical board. Consent for publicationNot applicable. Competing interestsLUW is an employee and shareholder of Gloriana Therapeutics, Inc., and Sinfonia Biotherapeutics AB. Other authors declare that they have no competing interest. Competing interests LUW is an employee and shareholder of Gloriana Therapeutics, Inc., and Sinfonia Biotherapeutics AB. Other authors declare that they have no competing interest."

"Funding Open access funding provided by Karolinska Institute. We would like to gratefully acknowledge the funding that supported this research namely ALF Medicine Stockholm, Demensfonden, Åhléns foundation, Magnus Bergvall foundation, Stohnes Stiftelse, Gamla Tjänarinnor, Foundation for Geriatric Diseases at Karolinska Institutet, Loo and Hans Osterman Foundation, Karolinska Institutet Research Fund, Hållsten Research Foundation, Olle Engkvist Foundation, Swedish Research Council (2020–02014), Swedish Brain Foundation, Torsten Söderberg Foundation, Sonja Leikrans donation, Erling Persson Foundation, and Ake Weiberg Foundation."