Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer's disease pathology in the 5xFAD mouse.

"Declarations Ethics approval and consent to participateAll experiments using mice to generate primary cell cultures or drug testing were carried out according to an Animal Use Protocol approved by the Institutional Animal Care and Use Committee at the University of Kentucky (Protocol No. 2017–2677). Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by grants to EB (National Institutes of Health: R01AG064234, R21AG078601, RF1AG078338; U.S. Department of Veterans Affairs: I01BX003643) and to SMC (BrightFocus Grant Submission No.: A20201464F; National Institute On Aging of the National Institutes of Health under Award Number P30AG028383). PGS and HV received support from Kentucky Spinal Cord and Head Injury Research Trust (KSCHIRT chair #3)."