Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk.

"data availability the gwas for tobacco smoking and alcohol drinking can be obtained through the gscan data portal ( https://conservancy umn edu/handle/11299/241912"

"Competing interests The authors declare no competing interests."

"Funding XL is supported by the Natural Science Fund for Distinguished Young Scholars of Zhejiang Province (LR22H260001) and the National Nature Science Foundation of China (No. 82204019). ET is supported by a CRUK Career Development Fellowship (C31250/A22804). AS acknowledges support from the Academy of Medical Sciences/the Wellcome Trust/the Government Department of Business, Energy and Industrial Strategy/the British Heart Foundation/Diabetes UK Springboard Award [SBF006\1109]. The work is supported by Programme Grant funding from Cancer Research UK (C348/A12076) and by funding for the infrastructure and staffing of the Edinburgh CRUK Cancer Research Centre. This work is also funded by a grant to MGD as Project Leader with the MRC Human Genetics Unit Centre Grant (U127527198). This work is also supported by the Natural Science Foundation of Zhejiang Province (LBY20H160002) to QX and the project of the regional diagnosis and treatment center of the Health Planning Committee (No. JBZX-201903) to KD."