RNA interference targeting ANGPTL3 for triglyceride and cholesterol lowering: phase 1 basket trial cohorts.

"Competing interests G.F.W. (corresponding author) reports personal fees for lectures from Amgen, Novartis and Sanofi; research grants from Amgen and Arrowhead Pharmaceuticals; and honoraria for serving on advisory boards from Amgen, AstraZeneca, Esperion, Novartis, Pfizer and Arrowhead Pharmaceuticals. J.H., B.G., S.M., J.S.M., T.C. and R.Z. are, or were recently, Arrowhead Pharmaceuticals employees and shareholders. I.G. reports being on advisory boards for Arrowhead Pharmaceuticals and Ionis. C.B. reports grant/research support (all substantial (>$10,000) and all paid to institution, not individual) from Akcea, Amgen, Arrowhead Pharmaceuticals, Esperion, Ionis, Merck, Novartis, Novo Nordisk, Regeneron and National Institutes of Health and consultant for 89Bio, Alnylam Pharmaceuticals, Althera, Amarin, Amgen, Arrowhead Pharmaceuticals, AstraZeneca, Denka Seiken*, Eli Lilly, Esperion, Genentech, Gilead, Illumina, Matinas BioPharma, Merck, New Amsterdam*, Novartis, Novo Nordisk, Pfizer, Regeneron and Sanofi-Synthelabo (*substantial where noted). P.G. reports being principal investigator for Verve101 and receiving consulting fees from Verve Therapeutics. R.H. reports consulting fees from Acasti, Akcea/Ionis, Amgen, Amryt, Arrowhead Pharmaceuticals, Boston Heart, HLS Therapeutics, Pfizer, Novartis, Regeneron, Sanofi and Ultragenyx. D.G. reports grants and/or personal fees from Arrowhead Pharmaceuticals, Acasti, Amgen, Kowa, Regeneron, Uniqure, Akcea, Allergan, Amryt, CRISPR Therapeutics, Eli Lilly, Ionis, Novartis, Biogen, Sanofi, Novo Nordisk, Pfizer, Verve Therapeutics, Aegerion, Applied Therapeutics, AstraZeneca, Boehringer Ingelheim, Ceapro, Dalcor, Esperion and The Medicine Company. D.S. reports honoraria for serving on advisory boards from Regeneron, Amgen, AstraZeneca, Amarin, Esperion, Novartis and Sanofi, outside the submitted work. No competing interests are reported by C.S., P.C., R.S., J.B. and J.K."

"This study was supported by Arrowhead Pharmaceuticals, Inc. We thank the patients for their participation in the AROANG1001 study and the staff at each clinical trial site. The study was designed by the lead principal investigator and Arrowhead Pharmaceuticals, Inc. Arrowhead Pharmaceuticals, Inc. contributed to data collection and data interpretation in collaboration with all investigators, funded data analyses and participated in manuscript preparation with all authors. We thank J. Abbott from Arrowhead Pharmaceutical, Inc. for medical writing support, which was funded by Arrowhead Pharmaceuticals, Inc. in accordance with Good Publication Practice guidelines (http://www.ismpp.org/gpp3)."