Evaluation of pediatric epigenetic clocks across multiple tissues.

"Declarations Ethics approval and consent to participateThe ECHO-wide Cohort Data Collection Protocol operates under a single Institutional Review Board (IRB) administered by the Western Institutional Review Board (WIRB) Copernicus Group IRB, which is registered with both the Office for Human Research Protections (OHRP) and the FDA as IRB00000533. Compliance with regulatory requirements for the ECHO-wide Cohort Data Collection Protocol at participating cohort sites is the responsibility of properly constituted Institutional Review Boards, which can either be the ECHO single IRB or the ECHO cohort's local IRB. These governing IRBs review ECHO protocols, as well as informed consent/assent forms, HIPAA authorization forms, recruitment materials, and other relevant information before any ECHO-wide Cohort Data Collection Protocol-related procedures or activities can begin. The ECHO Data Analysis Center's work is approved by the Institutional Review Board at the Johns Hopkins Bloomberg School of Public Health. ECHO Cohort Investigators, or their designated study personnel, obtained written informed consent from all participants in the current study for both ECHO-wide Cohort Data Collection Protocol participation and participation in their specific cohorts. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of the Director, National Institutes of Health, under Award Numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 with co-funding from the Office of Behavioral and Social Science Research (PRO Core). The following grants supported data collection: Project Viva is supported by NIH UH3OD023286 (Oken) and R01HD034568; The Healthy Start Study is funded by the National Institutes of Health (NIH) R01DK076648 and UH3OD023248 (Dabelea). The URECA studies are supported by NIH grants UG3/UH3OD023282 (Gern), UM1 AI114271, and UM1 AI160040; ARCH is supported by NIH UG3OD023285 and UH3OD023285 (Kerver); MADRES is supported by UH3OD023287 (Breton); ECHO-NOVI is supported by R01HD072267, UG3OD023347, UH3OD023347 (Lester), and R01HD084515; UH3OD023318 (Dunlop), R01MD009064 (Smith/Dunlop). UH3OD023253(Camargo); UH3OD023275(Karagas); UH3OD023271(Karr); UH3OD023288(McEvoy); UH3OD023342(Lyall); UH3OD023348 (O’Shea); UH3OD023290 (Herbstman) and UH3OD023305 (Trasande). Dr. Perng is supported by the Center for Clinical and Translational Sciences Institute KL2-TR002534 and ADA-7-22-ICTSPM-08."