Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers.

"Disclosures: Dr. Andreassen has received speakers honorarium from Lundbeck, Janssen and Sunovion, and is a consultant to coretechs.ai. Dr. Reis Marques reports personal fees from Pfizer, Lundbeck, Astellas, Janssen and Angelini outside the submitted work. He is an employee and shareholder of Pasithea Therapeutics. Dr. Ching has received partial research support from Biogen, Inc. (Boston, USA) for work unrelated to the topic of this manuscript (PI Paul Thompson). Dr. Thompson has received partial research support from Biogen, Inc. (Boston, USA) for work unrelated to the topic of this manuscript. Dr. van den Bree reports grants from Takeda Pharmaceuticals, outside the submitted work. Dr. Grabe has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care. All other authors declare no competing financial interests."

"1000BRAINS: The 1000BRAINS-Study was funded by the Institute of Neuroscience and Medicine, Research Centre Jülich, Germany. We thank the Heinz Nixdorf Foundation (Germany) for the generous support of the Heinz Nixdorf Study. We also thank the scientists and the study staff of the Heinz Nixdorf Recall Study and 1000BRAINS. Furthermore, this project has received funding from the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No. 945539 (HBP SGA3; SC). This research was additionally supported by the Joint Lab “Supercomputing and Modeling for the Human Brain”. We gratefully acknowledge the computing time granted through JARA-HPC on the supercomputer JURECA at Forschungszentrum Jülich. ENIGMA-CNV working group: IES is supported by the Research Council of Norway (#223273), South-Eastern Norway Regional Health Authority (#2020060), European Union’s Horizon2020 Research and Innovation Programme (CoMorMent project; Grant #847776) and Kristian Gerhard Jebsen Stiftelsen (SKGJ-MED-021). RB is supported by South-Eastern Norway Regional Health Authority (#2020060). CEB is supported by NIMH U01MH119736, R21MH116473 and R01MH085953 This work was performed on Services for sensitive data (TSD), University of Oslo, Norway, with resources provided by UNINETT Sigma2 - the National Infrastructure for High Performance Computing and Data Storage in Norway. ECHO-DEFINE: The ECHO study acknowledges funding from the Wellcome Trust (Institutional Strategic Support Fund (ISSF)) to Marianne B.M van den Bree and Clinical Research Training Fellowship to Joanne L. Doherty (102003/Z/13/Z)), the Waterloo Foundation (WF 918-1234 to Marianne B.M van den Bree), the Baily Thomas Charitable Fund (2315/1 to Marianne B.M van den Bree), National Institute of Mental Health (NIMH 5UO1MH101724 and NIMH U01MH119738 to Marianne B.M van den Bree), the IMAGINE-ID and IMAGINE-2 studies (funded by Medical Research Council (MRC; MR/N022572/1 and MR/T033045/1 to Marianne B.M van den Bree) and a Medical Research Council (MRC) Centre Grant to Michael J. Owen (MR/P005748/1). The DEFINE study was supported by a Wellcome Trust Strategic Award (100202/Z/12/Z) to Michael J. Owen. UCLA-Utrecht: This study was supported by NIMH grant number: R01 MH090553 (to RAO). The NIMH had no further role in study design, in the collection, analysis and interpretation of the data, in the writing of the report, and in the decision to submit the paper for publication. QTIM: The QTIM study was supported by grants from the US National Institute of Child Health and Human Development (R01 HD050735) and the Australian National Health and Medical Research Council (NHMRC) (486682, 1009064). Genotyping was supported by NHMRC (389875). BETULA: Supported by a Scholar grant from Knut and Alice Wallenberg’s (KAW) foundation to Lars Nyberg. Freesurfer calculations were enabled by resources provided by the Swedish National Infrastructure for Computing (SNIC) at HPC2N, Umeå. SHIP: SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603, 01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs and the Social Ministry of the Federal State of Mecklenburg-West Pomerania. Genome-wide data in SHIP have been supported by the Federal Ministry of Education and Research (grant no. 03ZIK012) and a joint grant from Siemens Healthcare, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania. MRI scans in SHIP and SHIP-TREND have been supported by a joint grant from Siemens Healthcare, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania. PAFIP: This work was supported by the Instituto de Salud Carlos III (00/3095, 01/3129, PI020499, PI14/00639, PI17/01056 and PI14/00918), SENY Fundació Research Grant CI2005 0308007 and Fundación Marqués de Valdecilla. Instituto de investigación sanitaria Valdecilla (A/02/07, NCT0235832 and NCT02534363). OSAKA: This research was supported by AMED (grant number JP21wm0425012 and JP18dm0307002) and JSPS KAKENHI (grant number JP20H03611). This work was partially supported by JSPS KAKENHI (Grant Number JP22H04926 and 20K15778) and by grants from the Japan Agency for Medical Research and Development (AMED) (JP22wm0425012, JP22wm0525019, and JP22dk0207060). Some computations were performed at the Research Center for Computational Science, Okazaki, Japan (Project: NIPS, 18-IMS-C162, 19-IMS-C181, 20-IMS-C162, 21-IMS-C179, 22-IMS-C195).IMAGEN: received support from the European Union-funded FP6 Integrated Project IMAGEN (Reinforcement-related behavior in normal brain function and psychopathology) (LSHM-CT-2007-037286), the Horizon 2020 funded ERC Advanced Grant ‘STRATIFY’ (Brain network based stratification of reinforcement-related disorders) (695313), the Medical Research Foundation and Medical Research Council (grants MR/R00465X/1 and MRF-058-0004-RG-DESRI: ‘Neurobiological underpinning of eating disorders: integrative biopsychosocial longitudinal analyses in adolescents’; MR/S020306/1 and MRF-058-0009-RG-DESR-C0759: ‘Establishing causal relationships between biopsychosocial predictors and correlates of eating disorders and their mediation by neural pathways’), the National Institutes of Health (NIH) funded Consortium grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centres of Excellence, and 1R56AG058854-01, the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) and King’s College London (KCL), ERANID (Understanding the Interplay between Cultural, Biological and Subjective Factors in Drug Use Pathways) (PR-ST-0416-10004), BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics) (MR/N027558/1), Human Brain Project (HBP SGA 2, 785907), the FP7 project MATRICS (603016), the Medical Research Council Grant 'c-VEDA’ (Consortium on Vulnerability to Externalizing Disorders and Addictions) (MR/N000390/1), the Bundesministerium für Bildung und Forschung (BMBF grants 01GS08152; 01EV0711; Forschungsnetz AERIAL 01EE1406A, 01EE1406B), the Deutsche Forschungsgemeinschaft (DFG grants SM 80/7-2, SFB 940/2, NE 1383/14-1), the ANR (ANR-12-SAMA-0004, AAPG2019 – GeBra), the Eranet Neuron (AF12-NEUR0008-01 – WM2NA; and ANR-18-NEUR00002-01 – ADORe), the Fondation de France (00081242), the Fondation pour la Recherche Médicale (DPA20140629802), the Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), the Assistance-Publique-Hôpitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012, the Fondation de l’Avenir (grant AP-RM-17-013), the Fédération pour la Recherche sur le Cerveau. Further support was provided by grants from: ANR (project AF12-NEUR0008-01 - WM2NA, and ANR-12-SAMA-0004), the Fondation de France, the Fondation pour la Recherche Médicale, the Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), the Assistance-Publique-Hôpitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012; ANR (project AF12-NEUR0008-01 - WM2NA, ANR-12-SAMA-0004), the Eranet Neuron (ANR-18-NEUR00002-01), the Fondation de France (00081242), the Fondation pour la Recherche Médicale (DPA20140629802), the Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), the Assistance-Publique-Hôpitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012, the fondation de l’Avenir (grant AP-RM-17-013). MCIC: The MCIC study was supported by the National Institutes of Health (NIH/NCRR P41RR14075 and R01EB005846 (to Vince D. Calhoun)), the Department of Energy (DE-FG02-99ER62764), the Mind Research Network, the Morphometry BIRN (1U24, RR021382A), the Function BIRN (U24RR021992-01, NIH.NCRR MO1 RR025758-01, NIMH 1RC1MH089257 to Vince D. Calhoun), the Deutsche Forschungsgemeinschaft (research fellowship to Stefan Ehrlich), and a NARSAD Young Investigator Award (to Stefan Ehrlich). NTR: The NTR cohort was supported by the Netherlands Organization for Scientific Research (NWO) and The Netherlands Organisation for Health Research and Development (ZonMW) grants 904-61-090, 985-10-002, 912-10-020, 904-61-193, 480-04-004,463-06-001, 451-04-034, 400-05-717, Addiction-31160008, 016-115-035, 481-08-011, 056-32-010, Middelgroot-911-09-032, OCW_NWO Gravity programme—024.001.003, NWO-Groot 480-15-001/674, Center for Medical Systems Biology (CSMB, NWO Genomics), NBIC/BioAssist/RK(2008.024), Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL, 184.021.007 and 184.033.111); Spinozapremie (NWO-56-464-14192), KNAW Academy Professor Award (PAH/6635) and University Research Fellow grant (URF) to Dorret I. Boomsma; Amsterdam Public Health research institute (former EMGO+), Neuroscience Amsterdam research institute (former NCA); the European Science Foundation (ESF, EU/QLRT-2001-01254), the European Community’s Seventh Framework Programme (FP7-HEALTH-F4-2007-2013, grant 01413: ENGAGE and grant 602768: ACTION); the European Research Council (ERC Starting 284167, ERC Consolidator 771057, ERC Advanced 230374), Rutgers University Cell and DNA Repository (NIMH U24 MH068457-06), the National Institutes of Health (NIH, R01D0042157-01A1, R01MH58799-03, MH081802, DA018673, R01 DK092127-04, Grand Opportunity grants 1RC2 MH089951 and 1RC2 MH089995); the Avera Institute for Human Genetics, Sioux Falls, South Dakota (USA). Part of the genotyping and analyses were funded by the Genetic Association Information Network (GAIN) of the Foundation for the National Institutes of Health. Computing was supported by NWO through grant 2018/EW/00408559, BiG Grid, the Dutch e-Science Grid and SURFSARA. OATS: The OATS cohort has been funded by a National Health & Medical Research Council (NHMRC) and an Australian Research Council (ARC) Strategic Award Grant of the Ageing"