Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation.

"Declaration of interests The authors declare no competing interests."

"We thank Dr. Kazuo Takayama for his excellent advice. This research was financially supported by the Japan Agency for Medical Research and Development, 10.13039/100009619AMED (grant numbers 23fk0310512h0002, 23mk0101213h0003); Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research [BINDS]) from 10.13039/100009619AMED (grant number JP23ama121052); the Japan Society for the Promotion of Science (10.13039/501100001691JSPS) 10.13039/501100001691KAKENHI (grant number 21K18247). Graphical abstract was created using Biorender (https://biorender.com). Author contributionsThe author’s contributions to this paper are presented below using the CRediT taxonomy.Conceptualization: H.M.; Methodology: T.S. and J.I.; Validation: T.S. and C.I.; Formal Analysis: T.S. and C.I.; Investigation: T.S., C.I., and A.W.; Resources: H.M.; Data Curation: T.S. and C.I.; Writing – Original Draft: T.S., Y.T., and H.M.; Writing –Review & Editing: T.S., C.I., J.I., Y.T., and H.M.; Visualization: T.S. and C.I.; Supervision: H.M.; Project Administration: H.M.; Funding Acquisition: Y.T. and H.M."