Kidney Function and Risk of Renal Cell Carcinoma.

"model training used flexible parametric survival models with follow-up time as a time scale with the following covariates included in all models: the logit of the singleton risk score presence or absence of crp and egfr (supplementary data s1 equations1-3).; knots were placed in accordance with the singleton and colleagues' model (model in supplementary data s1 equation 2).; after recalibrating the singleton and colleagues' model in the ukb and incorporating crp (supplementary data s1 equation 2) the e/o ratio slightly improved [1 year e/o: 0 97 (95% ci 0 66-1 58); 10 years e/o: 1 02 (95% ci 0 90-1 10); fig 2 ].; we subsequently incorporated egfr creat-cystc and crp into the risk model - the updated model (supplementary data s1 equation 3) which was well-calibrated across the follow-up period [1-year e/o: 0 89 (95% ci 0 65-1 47); 10-year e/o: 1 08 (95% ci 0 93-1 14)]."

"Authors' Disclosures R.M. Martin reports grants from Cancer Research UK during the conduct of the study. D.C. Muller reports grants from Cancer Research UK during the conduct of the study, grants from Cancer Research UK, and grants from NIH/NCI outside the submitted work. No disclosures were reported by the other authors."

"This research was supported by Cancer Research UK 25 (C18281/A29019) programme grant (The Integrative Epidemiology Programme). R.M. Martin is a National Institute for Health Research senior investigator (NIHR202411). R.M. Martin is supported by a Cancer Research UK 25 (C18281/A29019) programme grant (the Integrative Cancer Epidemiology Programme). R.M. Martin is also supported by the NIHR Bristol Biomedical Research Centre that is funded by the NIHR (BRC-1215–20011) and is a partnership between University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol. R.M. Martin is affiliated with the Medical Research Council Integrative Epidemiology Unit at the University of Bristol which is supported by the Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4) and the University of Bristol. Authors' Disclosures: R.M. Martin reports grants from Cancer Research UK during the conduct of the study. D.C. Muller reports grants from Cancer Research UK during the conduct of the study, grants from Cancer Research UK, and grants from NIH/NCI outside the submitted work. No disclosures were reported by the other authors. Authors' Contributions: K. Alcala: Conceptualization, data curation, formal analysis, investigation, visualization, methodology, writing–original draft, writing–review and editing. H. Zahed: Validation, writing–review and editing. R. Cortez Cardoso Penha: Data curation, formal analysis. N. Alcala: Methodology, writing–review and editing. H.A. Robbins: Methodology, writing–review and editing. K. Smith-Byrne: Writing–review and editing. R.M. Martin: Funding acquisition, writing–review and editing. D.C. Muller: Writing–review and editing. P. Brennan: Funding acquisition, writing–review and editing. M. Johansson: Resources, supervision, investigation, writing–original draft, project administration, writing–review and editing."