Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences.

"Declarations Ethics approval and consent to participateThis study was approved by the OHSU Internal Review Board with a waiver of consent (STUDY00023667). Clinical information was collected under a separate, OHSU IRB approved Neurosurgery/Neuropathology Data Repository (STUDY00018995). Consent for publicationNot applicable. Competing interestsThe authors have no relevant conflicts of interest to disclose. Competing interests The authors have no relevant conflicts of interest to disclose."

"Funding This work was funded by the OHSU Pediatric Brain Tumor Program and by an OHSU School of Medicine Research Pilot Award (MDW). The OHSU Gene Profiling Shared Resource RRID: SCR_009975, a unit of the Integrated Genomics Laboratory, and the Histopathology Shared Resource receive financial support from the OHSU Knight Cancer Institute NCI Cancer Center Support Grant P30CA069533."