Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor.

"data availability statement all raw ngs datasets generated in this work are accessible publicly via gene expression omnibus (geo) under accession number gse237132 . data availability statement all raw ngs datasets generated in this work are accessible publicly via gene expression omnibus (geo) under accession number gse237132"

"Disclosure statement No potential conflict of interest was reported by the author(s)."

"We thank the Division of Cancer Treatment and Diagnosis (DCTD) Tumour Repository, the NCI, for providing the IGROV-1 cell line. We are grateful for the excellent services provided by Ze Ming Lim of the Duke-NUS FACS Core, as well as Angie Lay Keng Tan, Su Ting Tay and Thaleia Xuewen Ong of the Duke-NUS Genome Biology Facility. We thank the support provided by the Duke-NUS ABSL3 Facility. Figure 4(A) was produced using https://www.Biorender.com. During the preparation of this manuscript some authors used OpenAI ChatGPT in order to paraphrase some of their original sentences to enhance the readability of the manuscript. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Conceptualization MY, YSO; Methodology MY, WSL, WOYC, SG, XY, DEA, CWT, YSO; Formal Analysis MY, WOYC, LW, CA, SG, CWT, YSO; Investigation MY, WSL, WH, MGM, JMD, CLY, BY, DT, WRS, AMG, JY, XY, DEA, CWT, YSO; Resources SL, AH, XY, ML, SG, DEA, GJDS, LFW, YSO; Writing – Original Draft MY, YSO; Writing – Review & Editing MY, WSL, WOYC, MGM, AH, ML, SG, DEA, CWT, LFW, YSO; Visualization MY, WSL, WOYC, CWT; Supervision DEA, GJDS, CWT, LFW, YSO; Project Administration GJDS, LFW, YSO; Funding Acquisition DEA, GJDS, LFW, YSO."