Damage-associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury.

"Declarations Ethics approval and consent to participateThis single-center observational study was approved by the Ethics Committee of the Ethics Committee of Kagoshima University Graduate School of Medical and Dental Sciences and Kagoshima City Hospital. Consent for publicationNot applicable. Competing interestsThe ELISA for histone H3 is a product-in development of the Shino-Test Corporation, where SY is an employee. IM holds an endowed chair at Kagoshima University and receives research funding from the Shino-Test Corporation. The funding is for academic promotion and is not directly related to the present study. The remaining authors declare that they have no competing interests. Competing interests The ELISA for histone H3 is a product-in development of the Shino-Test Corporation, where SY is an employee. IM holds an endowed chair at Kagoshima University and receives research funding from the Shino-Test Corporation. The funding is for academic promotion and is not directly related to the present study. The remaining authors declare that they have no competing interests."

"Funding This work was supported by research grants from the Japan Society for the Promotion of Science."