Optimized infusion rates for N,N-dimethyltryptamine to achieve a target psychedelic intensity based on a modeling and simulation framework.

Authors:
Eckernäs E; Koomen J; Timmermann C; Carhart-Harris R; Röshammar D and 1 more

Journal:
CPT Pharmacometrics Syst Pharmacol

Publication Year: 2023

DOI:
10.1002/psp4.13037

PMCID:
PMC10583250

PMID:
37675853

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Journal Information

Full Title: CPT Pharmacometrics Syst Pharmacol

Abbreviation: CPT Pharmacometrics Syst Pharmacol

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Pharmacology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

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"the model code is provided in data s1 .; a simulated dataset is provided in data s2 .; data s1 click here for additional data file.; data s2 click here for additional data file."

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"CONFLICT OF INTEREST STATEMENT E.E. and M.A. are employees of Sahlgrenska Academy at the University of Gothenburg. C.T. is an employee of the Centre for Psychedelic Research, Imperial College London. All other authors declared no competing interests for this work."

Evidence found in paper:

"FUNDING INFORMATION The clinical study was funded by the Centre for Psychedelic Research, Imperial College London. E.E. is partly supported by the Sahlgrenska Academy at the University of Gothenburg."

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Last Updated: Aug 05, 2025