The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice.

"Declarations Conflicts of interestThe authors declare that they have no conflict of interest. Ethics standardsThe study was approved by the Ethics Committee of the local animal welfare body (ICBAS-UP ORBEA) and the Portuguese national authority for animal health (DGAV, processes no. 0421/000/000/2016) and certify that the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki. Informed consentNot applicable. Conflicts of interest The authors declare that they have no conflict of interest."

"Funding Open access funding provided by FCT|FCCN (b-on). Ana Reis-Mendes and Vera Marisa Costa acknowledge FCT for their Grants: SFRH/ BD/129359/2017 and SFRH/BPD/110001/2015, respectively, being the latter funded by national funds through FCT—Fundação para a Ciência e a Tecnologia, I.P., under the Norma Transitória—DL57/2016/ CP1334/CT0006. This work was funded by national funds from FCT-Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences-UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy-i4HB. We greatly acknowledge Celeste Resende for her assistance in histological procedures."