FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.

"data availability the datasets generated during and/or analyzed during the current study are available in the proteomexchange repository pxd04419246 [ 46 ]."

"Competing interests The authors declare no competing interests."

"We would like to thank the University of Utah Flow Cytometry Shared Resource Laboratory, Division of Hematology Biorepository at Huntsman Cancer Institute, UNMC Flow Cytometry Research Facility and UNMC Mass Spectrometry and Proteomics Core Facility for expert assistance. The UNMC core facilities are administrated through the Office of the Vice Chancellor for Research and supported by state funds from the Nebraska Research Initiative (NRI) and The Fred and Pamela Buffett Cancer Center’s National Cancer Institute Cancer Support Grant. Human CD34+ cells were available with the support of Cooperative Centers of Excellence in Hematology NIDDK Grant # DK106829. KJW was supported by the UNMC Internal Fellowship. SMB is supported by the National Institutes of Health P20GM121316, 1R37CA262635-01, and 1R01AI53090-01A1. SAS, RKH and SMB are supported by the UNMC Pediatric Cancer Group. This publication was supported by the Huntsman Cancer Institute at the University of Utah, supported by the National Cancer Institute of the National Institutes of Health (NIH) under award number P30CA042014 and Fred & Pamela Buffett Cancer Center Support Grant from the National Cancer Institute under award number P30CA036727."