Cysteine Enrichment Mediates Co-Option of Uricase in Reptilian Skin and Transition to Uricotelism.

"atomic coordinates and structure factors have been deposited in the protein data bank with entry codes8ofk 8oh8 8oih and 8oiw. data availability the datasets and computer code used in this study are available in github at the address: https://github com/lab83bio/aa_comp ."

"data availability the datasets and computer code used in this study are available in github at the address: https://github com/lab83bio/aa_comp ."

"We thank Davide Cavazzini and Marialaura Marchetti for assistance, Francesco Trigiante and Luciano Macaluso for their help in the initial phase of the work, and Lorenzo Alibardi for valuable discussions. Scientists and staff at Diamond Light Source (Didcot, UK) are gratefully acknowledged for their support. This work benefited from the equipment and framework of the COMP-HUB and COMP-R initiatives, funded by the “Departments of Excellence” program of the Italian Ministry for University and Research (MIUR, 2018-2022 and MUR, 2023-2027), and from the High Performance Computing facility of the University of Parma, Italy. G.M. is a recipient of postdoctoral fellowships from COMP-HUB. This work was supported by the Italian Ministry for Education, University and Research PRIN grant 2017483NH8 to R.P. and by the United Kingdom Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/P000169/1 awarded to R.A.S."