The guanine nucleotide exchange factor Rin-like controls Tfh cell differentiation via CD28 signaling.

"the rna-seq data generated during this study are available through gene expression omnibus accession number gse235805 ."

"Disclosures: M. Iannacone consults or sits on advisory boards for the following companies: Asher Biotherapeutics, San Carlos, CA; GentiBio, Cambridge, MA; Clexio Biosciences, Petach Tikva, Israel; Sybilla Biotech, Trento, Italy; BlueJay Therapeutics, San Mateo, CA; Bristol Myers Squibb, New York, NY; and Aligos Therapeutics, South San Francisco, CA. No other disclosures were reported."

"This study has been funded by the Austrian Science Foundation through projects P19223 (R. Herbst), F7005, and doc.funds (DOC) Programme 32 (W. Ellmeier), P27747 and P35436 (S. Sakaguchi), and P24265, P30885, and F7004 (all N. Boucheron). B. Woller was supported by the DOC-fFORTE Programme from the Austrian Academy of Sciences. L. Sandner received an EFIS-IL Short-term Fellowship for a research stay at Vita San Raffaele University and Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy. M. Kuka has been supported by the Italian Ministry of University and Research grants PRIN-2017ZXT5WR and PRIN-20209Y5YFZ. Author contributions: Conceptualization: L. Sandner, W. Ellmeier, R. Herbst, and N. Boucheron. Methodology: L. Sandner, A. Schebesta, S. Sakaguchi, E. Sala, M. Kuka, T. Frey, K. Schmetterer, B. Woller, and I. Taniuchi. Investigation: L. Sandner, N. Boucheron, M. Alteneder, C. Zhu, R. Rica, M. Khan, P. Hoffmann, A. Schebesta, S. Sakaguchi, M. Madern, A. Tosevska, M. Bonelli, B. Woller, I. Taniuchi, E. Sala, M. Kuka, T. Frey, K. Schmetterer, and R. Herbst. Visualization: L. Sandner, A. Schebesta, and A. Tosevska. Funding acquisition: N. Boucheron, R. Herbst, S. Sakaguchi, L. Sandner, B. Woller, and W. Ellmeier. Project administration: L. Sandner and N. Boucheron. Supervision: N. Boucheron. Writing—original draft: L. Sandner, N. Boucheron, S. Sakaguchi, and W. Ellmeier. Writing—review & editing: L. Sandner, M. Alteneder, R. Rica, B. Woller, E. Sala, T. Frey, A. Tosevska, M. Madern, M. Bonelli, M. Khan, M. Iannacone, M. Kuka, W. Ellmeier, S. Sakaguchi, R. Herbst, N. Boucheron. L. Sandner, W. Ellmeier, R. Herbst, and N. Boucheron designed the research; L. Sandner performed most of the experiments and analyzed the data. M. Alteneder, C. Zhu, R. Rica, and P. Hoffmann contributed to in vivo experiments; A. Schebesta performed semiquantitative PCR analysis; S. Sakaguchi contributed to LCMV infection experiments and analyzed data. L. Sandner, M. Madern, A. Tosevska, and M. Bonelli performed bioinformatics analysis; B. Woller, W. Ellmeier, R. Herbst, and I. Taniuchi generated the Rinl-KO mice; E. Sala, M. Kuka, and M. Iannacone performed confocal microscopy experiments; T. Frey and K. Schmetterer performed CRISPR-Cas9 mediated deletion in human CD4+ T cells; M. Kuka contributed to revision experiments; L. Sandner and N. Boucheron wrote the manuscript with contributions from all co-authors."