Ultrasensitive proteomics depicted an in-depth landscape for the very early stage of mouse maternal-to-zygotic transition.

"ms proteomics data have been deposited to the proteomexchange consortium [ ] via the proteomics identification database (pride) [ ] partner repository with the dataset identifiers pxd041399 and pxd041023."

"Declaration of competing interest Yi Shen, Junfeng Zhang, Huiping Zhang, and Ziyi Li are employees of Shanghai Applied Protein Technology Co., Ltd. (Shanghai, China). The authors declare that there are no conflicts of interest."

"We thank all members of our laboratories for helpful discussions. This work was supported by the National Natural Science Foundation of China (NSFC) (Grant Nos.: 82030099 and 30700397), the National Key R&D Program of China (Grant No.: 2022YFD2101500), the Science and Technology Commission of Shanghai Municipality, China (Grant No.: 22DZ2303000), the Shanghai Municipal Science and Technology Commission “Science and Technology Innovation Action Plan” Technical Standard Project, China (Grant No.: 21DZ2201700), the Shanghai Municipal Science and Technology Commission “Science and Technology Innovation Action Plan” Natural Science Foundation Project, China (Grant No.: 23ZR1435800), the Strategic Priority Research Program of the Chinese Academy of Sciences, China (Grant No.: XDB32060000), the Basic Frontier Scientific Research Program of Chinese Academy of Sciences (Grant No.: ZDBS-LY-SM019), the Yangfan Project of Shanghai Science and Technology Commission, China (Grant No.: 22YF1454100), and the Innovative Research Team of High-level Local Universities in Shanghai, China. We also thank the help from Dr. Chengpin Shen in Shanghai Omicsolution Co., Ltd. for database searching of partial mass spectrometry data. Lei Gu and Xumiao Li: Methodology, Validation, Formal analysis, Investigation, Data curation, Writing - Original draft preparation, Reviewing and Editing, Visualization; Wencheng Zhu: Methodology, Validation, Investigation, Data curation, Writing - Original draft preparation, Reviewing and Editing, Visualization, Funding acquisition; Yi Shen: Methodology, Validation, Software, Formal analysis, Investigation, Data curation, Writing - Reviewing and Editing, Visualization; Qinqin Wang: Formal analysis, Investigation, Visualization, Writing - Original draft preparation; Wenjun Liu: Formal analysis, Investigation, Validation, Writing - Reviewing and Editing; Junfeng Zhang: Data curation, Investigation, Validation, Writing - Reviewing and Editing; Huiping Zhang and Jingquan Li: Data curation, Project administration, Writing - Reviewing and Editing; Ziyi Li: Conceptualization, Supervision, Resources, Software, Writing - Reviewing and Editing; Zhen Liu: Conceptualization, Supervision, Funding acquisition, Writing - Reviewing and Editing; Chen Li: Conceptualization, Supervision, Funding acquisition, Writing - Original draft preparation, Reviewing and Editing; Hui Wang: Conceptualization, Resources, Supervision, Funding acquisition, Writing - Reviewing and Editing."