Spinal cord perfusion pressure correlates with breathing function in patients with acute, cervical traumatic spinal cord injuries: an observational study.

"Declarations Ethics approval and consent to participateApprovals for ISCoPE, including consent form and patient information sheet were obtained from the St. George's, University of London Joint Research Office, and the National Research Ethics Service London–St Giles Committee (No. 10/H0807/23). The study was performed in accordance with ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Informed consent was obtained from all participants included in the study or their family members. Consent for publicationNot applicable. Competing interestsSS and MCP are PI's on a research grant from Wings for Life spinal cord research foundation. MCP is Chairman of the Neurosciences Research foundation. AZ, EB and RV have no conflicts of interest. Competing interests SS and MCP are PI's on a research grant from Wings for Life spinal cord research foundation. MCP is Chairman of the Neurosciences Research foundation. AZ, EB and RV have no conflicts of interest."

"Funding Supported by research grant from the Wings for Life spinal cord research foundation (SS, MCP), research fellowships from the Royal College of Surgeons of England (RV) and the Neurosciences Research Foundation (RV), and salary support from the UK National Institute for Health Research Clinical Research Network (EB). The funding bodies did not influence the design of the study or the collection, analysis, and interpretation of data or the writing of the manuscript."

"TSCI patients were recruited as part of the Injured Spinal Cord Pressure Evaluation (ISCoPE) clinical study at St. George's Hospital, London, UK. Approvals for ISCoPE, including consent form and patient information sheet were obtained from the St. George's, University of London Joint Research Office, and the National Research Ethics Service London–St Giles Committee (No. 10/H0807/23). The study was performed in accordance with ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Informed consent was obtained from all participants included in the study or their family members. ISCoPE is registered at www.clinicaltrials.gov and www.ichgcp.net as NCT02721615. Inclusion criteria were: (1) TSCI American Spinal Injury Association Impairment Scale (AIS) grade A, B, or C; (2) age 18–70 years; (3) timing between TSCI and surgery within 72 h. Exclusion criteria were: (1) patient unable to consent; (2) other significant co-morbidities; (3) penetrating TSCI."