Serum metabolomics profiling by proton nuclear magnetic resonance spectrometry of the response to single oral macronutrient challenges in women with polycystic ovary syndrome (PCOS) compared with male and female controls.

"Declarations Ethics approval and consent to participateAll subjects provided their written informed consent, and the study was approved by the Ethics Committee of the Hospital Universitario Ramón y Cajal. Consent for publicationNot applicable. Competing interestsThe authors have no competing interests to declare. Competing interests The authors have no competing interests to declare."

"Funding This research was funded by Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation (Grants PI11/00357, PI15/01686, PIE16/00050, PI18/01122, and PI21/00116, Plan Estatal de I+D+i 2013–2016) and co-funded by the European Regional Development Fund “A way to make Europe”. CIBERDEM and IRYCIS are also initiatives of the Instituto de Salud Carlos III."