Prognostic Value of the Modified Rutgeerts Score for Long-Term Outcomes After Primary Ileocecal Resection in Crohn's Disease.

"CONFLICTS OF INTEREST Guarantor of the article: Annemarie C. de Vries, MD, PhD. Specific author contributions: M.T.J.B., S.t.B.H., A.C.d.V.: conception and design: M.T.J.B, S.t.B.H., F.H., A.G.L.B., G.D., M.J.R.-C., N.K.H.d.B., L.P.S.S., A.E.v.d.M.d.-J., R.L.W., O.v.R., C.v.d.W., A.C.d.V.: acquisition and interpretation of data: M.T.J.B., S.t.B.H., N.S.E., A.C.d.V.: analysis of data. All authors have participated in drafting or critically revising the manuscript and gave their final approval of the current version. Financial support: None to report. Potential competing interests: M.T.J.B. has served as speaker for Abbvie outside the submitted work. A.G.L.B. has served on the advisory board of Takeda, Abbvie, and Janssen outside the submitted work. Gerard Dijkstra has received a grant from Royal DSM and speaker fees from: Abbvie, Janssen-Cilag, Takeda, and Pfizer outside the submitted work. N.K.H.d.B. has served as a speaker for AbbVie and MSD and has served as consultant and principal investigator for TEVA Pharma BV and Takeda. He has received an (unrestricted) research grant from Dr. Falk, TEVA Pharma BV, MLDS, and Takeda, all outside the submitted work. F.H. has served on advisory boards or as speaker for Abbvie, Janssen-Cilag, MSD, Takeda, Celltrion, Teva, Sandoz, and Dr Falk, and has received funding (Grants/Honoraria) from Dr. Falk, Janssen-Cilag, Abbvie, and Takeda and consulting fees from Celgene and Janssen-Cilag, all outside the submitted work. L.P.S.S. has served as a speaker and received research support from Takeda, outside the submitted work. A.E.v.d.M.d.J. reports presentation fee from Janssen and has served on the advisory board of Takeda and Galapagos, outside the submitted work. R.L.W. has served on the advisory board and as invited speaker for Janssen, Pfizer, Takeda, and Galapagos, outside the submitted work. C.J.v.d.W. received grants and or fee for advisory boards and presentations from Pfizer, Abbvie, Celltrion, Falk Benelux, Takeda, Janssen, and Ferring, outside the submitted work. O.v.R. has served as invited speaker for Janssen-Cilag and has received nonfinancial support from Takeda, outside the submitted work. A.C.d.V. has served on advisory boards for Takeda, Janssen, Bristol Myers Squibb, Abbvie, Pfizer, and Galapagos and has received unrestricted research grants from Takeda, Janssen, and Pfizer, outside the submitted work. All other authors report no conflicts of interests. Ethical approval statement: The RAP-CD study was approved by the Medical Ethics Review Committee of the Erasmus Medical Center (METC-2017-482). The study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki. Study HighlightsWHAT IS KNOWN✓ The modified Rutgeerts score (mRS) is used for the assessment of postoperative recurrence in Crohn's disease.✓ The prognostic value of the mRS for long-term outcomes needs to be further elucidated, especially the impact of anastomotic lesions needs clarification.WHAT IS NEW HERE✓ The increasing mRS corresponds closely with the risk of surgical and clinical recurrence.✓ Moderate-to-severe lesions (≥i2b) are associated with surgical recurrence and mild-to-moderate lesions are associated with progression to severe endoscopic recurrence (i1 and i2b).✓ An mRS ≥ i1 is associated with clinical recurrence."

"Financial support: None to report."