Bleeding pattern and consumption of factor VIII concentrate in adult patients with haemophilia A without inhibitors in the Czech Republic between 2013 and 2021 (Czech National Haemophilia Programme registry data).

"Declarations Ethical approvalAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. Conflict of interestAuthor Gabriela Romanová declares that she has no conflicts of interest. Author Petr Smejkal has received a speaker honourarium from the following companies: Bayer, Novo Nordisk, Roche, Sobi and Takeda. Author Petra Ovesná declares that she has no conflicts of interest. Author Eva Drbohlavová has received a speaker honourarium from Company Sobi, Roche and Takeda. Author Petr Dulíček declares that he has no conflicts of interest. Author Zdeňka Hajšmanová declares that she has no conflicts of interest. Author Antonín Hluší declares that he has no conflicts of interest. Author Radomíra Hrdličková declares that she has no conflicts of interest. Author Jana Ullrychová declares that she has no conflicts of interest. Author IV declares that he has no conflicts of interest. Author Jan Blatný has received a speaker honourarium from NovoNordisk, Sobi, Roche and Takeda. Author Zuzana Čermáková declares that she has no conflicts of interest. Author Ester Zápotocká declares that she has no conflicts of interest. Author Miroslav Penka declares that he has no conflicts of interest. Conflict of interest Author Gabriela Romanová declares that she has no conflicts of interest. Author Petr Smejkal has received a speaker honourarium from the following companies: Bayer, Novo Nordisk, Roche, Sobi and Takeda. Author Petra Ovesná declares that she has no conflicts of interest. Author Eva Drbohlavová has received a speaker honourarium from Company Sobi, Roche and Takeda. Author Petr Dulíček declares that he has no conflicts of interest. Author Zdeňka Hajšmanová declares that she has no conflicts of interest. Author Antonín Hluší declares that he has no conflicts of interest. Author Radomíra Hrdličková declares that she has no conflicts of interest. Author Jana Ullrychová declares that she has no conflicts of interest. Author IV declares that he has no conflicts of interest. Author Jan Blatný has received a speaker honourarium from NovoNordisk, Sobi, Roche and Takeda. Author Zuzana Čermáková declares that she has no conflicts of interest. Author Ester Zápotocká declares that she has no conflicts of interest. Author Miroslav Penka declares that he has no conflicts of interest."

"Funding Open access publishing supported by the National Technical Library in Prague. This study was “Supported by Ministry of Health, Czech Republic—conceptual development of research organisation (FNBr, 65269705).”"