Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment.

"to assess whether these variables were more strongly associated with one tau biomarker than the other we computed 95% confidence intervals of the difference for the corresponding effect sizes (e g r age-pet versus r age-plasma ) using bootstrap resampling ( n = 1000 iterations); see supplementary material for example r code .; see supplementary material for r code .; in panel a the shaded area indicates95% ci of the regression line although associations tended to be stronger for pet compared to plasma bootstrap-based comparisons of the associations were only significant for age ( p = 0 003) but not for sex ( p = 0 21) apoe-4 carriership ( p = 0 81) or centiloids ( p = 0 09); see supplementary table 2 for full results and supplementary methods for corresponding r code .; supplementary methods : r code."

"Declarations Ethics approval and consent to participatePatients provided written, informed consent at the time of recruitment. The study was approved by the institutional review boards at UCSF, University of California, Berkeley, and Lawrence Berkeley National Laboratory. Consent for publicationNot applicable. Competing interestsNSM, EHT RS, DSM have nothing to disclose.JCR is a site PI for clinical trials sponsored by Eisai and Eli Lilly.LI is a full-time employee and minor stockholder of Eli Lilly and Company at the time of manuscript submission, although he was a UCSF employee during his involvement in the study.CET receives support from the European Commission (Marie Curie International Training Network, grant agreement No 860197 (MIRIADE), Innovative Medicines Initiatives 3TR (Horizon 2020, grant no 831434) EPND (IMI 2 Joint Undertaking (JU), grant No. 101034344) and JPND (bPRIDE), National MS Society (Progressive MS alliance), Alzheimer Association, Health Holland, the Dutch Research Council (ZonMW), Alzheimer Drug Discovery Foundation, The Selfridges Group Foundation, Alzheimer Netherlands. CT is recipient of ABOARD, which is a public-private partnership receiving funding from ZonMW (#73305095007) and Health~Holland, Topsector Life Sciences & Health (PPP-allowance; #LSHM20106). CET has a collaboration contract with ADx Neurosciences, Quanterix and Eli Lilly, performed contract research or received grants from AC-Immune, Axon Neurosciences, BioConnect, Bioorchestra, Brainstorm Therapeutics, Celgene, EIP Pharma, Eisai, Fujirebio, Grifols, Instant Nano Biosensors, Merck, Novo Nordisk, PeopleBio, Roche, Siemens, Toyama, Vivoryon. She had speaker contracts for Roche, Grifols, Novo Nordisk. She serves on editorial boards of Medidact Neurologie/Springer, Alzheimer Research and Therapy, Neurology: Neuroimmunology & Neuroinflammation.BLM receives research support from the NIH/NIA and the Centers for Medicare & Medicaid Services (CMS) as grants for the Memory and Aging Center. As an additional disclosure, Dr. Miller serves as Medical Director for the John Douglas French Foundation; Scientific Director for the Tau Consortium; Director/Medical Advisory Board of the Larry L. Hillblom Foundation; Scientific Advisory Board Member for the National Institute for Health Research Cambridge Biomedical Research Centre and its subunit, the Biomedical Research Unit in Dementia (UK); and Board Member for the American Brain Foundation (ABF).JLD is an inventor on patents or patent applications of Eli Lilly and Company relating to the assays, methods, reagents and / or compositions of matter related to measurement of P-tau217. He has served as a consultant for Genotix Biotechnologies Inc, Gates Ventures, Karuna Therapeutics, AlzPath Inc, Cognito Therapeutics, Inc., and received research support from ADx Neurosciences, AlzPath, Roche Diagnostics and Eli Lilly and Company in the past two years. He has received speaker fees from Eli Lilly and Company.WJJ receives research support from NIH/NIA, Roche/Genentech. He has received consulting fees from Bioclinica, Lilly, Eisai, and Biogen.GDR receives research support from Avid Radiopharmaceuticals, GE Healthcare, Genentech and Life Molecular Imaging, and has received consulting fees or speaking honoraria from Eli Lilly, GE Healthcare, Johnson & Johnson, Roche, Genentech, Merck. He is an associate editor of JAMA Neurology.ALB receives research support from NIH, the Rainwater Charitable Foundation, the Association for Frontotemporal Degeneration, Bluefield Project to Cure Frontotemporal Dementia, the GHR Foundation, the Alzheimer’s Drug Discovery Foundation, and the Alzheimer's Association. He has served as a consultant for Aeovian, AGTC, Alector, Arkuda, Arvinas, Boehringer Ingelheim, Denali, GSK, Life Edit, Humana, Oligomerix, Oscotec, Roche, TrueBinding and Wave, and received research support from Biogen, Eisai and Regeneron.RLJ is an associate editor for Alzheimer’s Research & Therapy. Competing interests NSM, EHT RS, DSM have nothing to disclose. JCR is a site PI for clinical trials sponsored by Eisai and Eli Lilly. LI is a full-time employee and minor stockholder of Eli Lilly and Company at the time of manuscript submission, although he was a UCSF employee during his involvement in the study. CET receives support from the European Commission (Marie Curie International Training Network, grant agreement No 860197 (MIRIADE), Innovative Medicines Initiatives 3TR (Horizon 2020, grant no 831434) EPND (IMI 2 Joint Undertaking (JU), grant No. 101034344) and JPND (bPRIDE), National MS Society (Progressive MS alliance), Alzheimer Association, Health Holland, the Dutch Research Council (ZonMW), Alzheimer Drug Discovery Foundation, The Selfridges Group Foundation, Alzheimer Netherlands. CT is recipient of ABOARD, which is a public-private partnership receiving funding from ZonMW (#73305095007) and Health~Holland, Topsector Life Sciences & Health (PPP-allowance; #LSHM20106). CET has a collaboration contract with ADx Neurosciences, Quanterix and Eli Lilly, performed contract research or received grants from AC-Immune, Axon Neurosciences, BioConnect, Bioorchestra, Brainstorm Therapeutics, Celgene, EIP Pharma, Eisai, Fujirebio, Grifols, Instant Nano Biosensors, Merck, Novo Nordisk, PeopleBio, Roche, Siemens, Toyama, Vivoryon. She had speaker contracts for Roche, Grifols, Novo Nordisk. She serves on editorial boards of Medidact Neurologie/Springer, Alzheimer Research and Therapy, Neurology: Neuroimmunology & Neuroinflammation. BLM receives research support from the NIH/NIA and the Centers for Medicare & Medicaid Services (CMS) as grants for the Memory and Aging Center. As an additional disclosure, Dr. Miller serves as Medical Director for the John Douglas French Foundation; Scientific Director for the Tau Consortium; Director/Medical Advisory Board of the Larry L. Hillblom Foundation; Scientific Advisory Board Member for the National Institute for Health Research Cambridge Biomedical Research Centre and its subunit, the Biomedical Research Unit in Dementia (UK); and Board Member for the American Brain Foundation (ABF). JLD is an inventor on patents or patent applications of Eli Lilly and Company relating to the assays, methods, reagents and / or compositions of matter related to measurement of P-tau217. He has served as a consultant for Genotix Biotechnologies Inc, Gates Ventures, Karuna Therapeutics, AlzPath Inc, Cognito Therapeutics, Inc., and received research support from ADx Neurosciences, AlzPath, Roche Diagnostics and Eli Lilly and Company in the past two years. He has received speaker fees from Eli Lilly and Company. WJJ receives research support from NIH/NIA, Roche/Genentech. He has received consulting fees from Bioclinica, Lilly, Eisai, and Biogen. GDR receives research support from Avid Radiopharmaceuticals, GE Healthcare, Genentech and Life Molecular Imaging, and has received consulting fees or speaking honoraria from Eli Lilly, GE Healthcare, Johnson & Johnson, Roche, Genentech, Merck. He is an associate editor of JAMA Neurology. ALB receives research support from NIH, the Rainwater Charitable Foundation, the Association for Frontotemporal Degeneration, Bluefield Project to Cure Frontotemporal Dementia, the GHR Foundation, the Alzheimer’s Drug Discovery Foundation, and the Alzheimer's Association. He has served as a consultant for Aeovian, AGTC, Alector, Arkuda, Arvinas, Boehringer Ingelheim, Denali, GSK, Life Edit, Humana, Oligomerix, Oscotec, Roche, TrueBinding and Wave, and received research support from Biogen, Eisai and Regeneron. RLJ is an associate editor for Alzheimer’s Research & Therapy."

"Funding The present study was supported by National Institutes of Health/National Institute of Aging grants NIH/NIA P30-AG062422 (to BLM, GDR), P01-AG019724 (to BLM), R01-AG045611 (to GDR), K99AG065501 (to RLJ) Rainwater Charitable Foundation (to GDR), Alzheimer’s Association (to RLJ, AARF:16–443577 and DSM, AACSF:19–617663), NIH/NIA R35 -AG072362 (GDR), Alzheimer’s Association ZEN-21–848216. NIH/NIA K23AG059888 (to JCR). NIH/NIA K23AG076960 (to DSM)."