Altered cfDNA fragmentation profile in hypomethylated regions as diagnostic markers in breast cancer.

"availability of data and materials raw sequencing data (fastq) have been deposited in the genome sequence archive in national genomics data center china national center for bioinformation (prjca019929 https://ngdc cncb ac cn/bioproject/ ). availability of data and materials raw sequencing data (fastq) have been deposited in the genome sequence archive in national genomics data center china national center for bioinformation (prjca019929"

"Declarations Ethics approval and consent to participateThis study was approved by the Institutional Review Board of Shenzhen University General Hospital and Huazhong University of Science and Technology Union Shenzhen Hospital according to established ethical guidelines as outlined in the Declaration of Helsinki. All patients signed an informed consent document approved by the Institutional Review Board before entering any study. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by National Natural Science Foundation of China (82241022, 82170070, 81970053) (DM.G); Joint project of basic research and applied basic research in Yunnan Province (202201AY070001-224) (DM.G); Shenzhen Fundamental Research Program (JCYJ20210324120206017) (DM.G); Shenzhen-Hong Kong Jointly Funded Project (SGDX20201103095404019) (DM.G); National Natural Science Foundation of China (89202586) (J.W); Open Project of Respiratory disease Clinical Medical Center of Yunnan Province (2022LCZXKF-HX04) (J.W); Shenzhen stable support for general projects (8940317–0109) (J.W); Science and Technology Project of Shenzhen Nanshan District (Health Care, 2018012) (HX.W); and Ningxia Natural Science Foundation (2019AAC03225) (YQ.H)."