Transcriptional mutagenesis of α-synuclein caused by DNA oxidation in Parkinson's disease pathogenesis.

"data availability tomograms of wt and s42y ?-syn fibrils have been deposited in the electron microscopy data bank under the accession codes emd-28752 and emd-28753 respectively. data availability tomograms of wt and s42y ?-syn fibrils have been deposited in the electron microscopy data bank under the accession codes emd-28752"

"The authors gratefully acknowledge NIH Neurobiobank for providing all post-mortem brain samples. The study was supported by NIH 1R01-NS100919 (to Y.S.K), 1R01-NS101461 (to Y.S.K), and NIH R35- GM136431 (to J.B). Authors would also like to acknowledge the contribution of Mr. Peter Kim, Ms. Anlissa Simon, Mr. Evan Adler, and Ms. Anishaa Sivakumar for their help with cloning, plasmid preparation, and characterization of S42Y antibody by western blotting. Authors gratefully acknowledge the contribution of Dr. Soumen Das and Dr. Greg Goldblatt for their help with the initial biophysical characterization of WT and S42Y aggregates."