The pseudokinase MLKL contributes to host defense against <i>Streptococcus pluranimalium</i> infection by mediating NLRP3 inflammasome activation and extracellular trap formation.

"s pluranimalium strain stp1 a clinical isolate of s pluranimalium (16s rdna sequencing analysis (figures s1a b) and specific 16s rdna gene sequence data deposited in ncbi genbank: oq073875) was isolated from nasal swab samples in ovine with signs of respiratory tract disease and was grown at 37?; wt (wild-type) and mlkl -/- ( mlkl -deficient) mice (per mouse) were intranasally challenged with 1 x 10 9 colony-forming units (cfus) of log-phase s pluranimalium strain stp1 a clinical isolate of s pluranimalium (16s rdna sequencing analysis (figures s1a b) and specific 16s rdna gene sequence data deposited in ncbi genbank: oq073875). data availability statement the data supporting the findings of this study are available from the corresponding author upon reasonable request. supplementary material supplemental data for this article can be accessed online at https://doi"

"Disclosure statement No potential conflict of interest was reported by the author(s)."