Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system.

"a matlab implementation of the model presented in this manuscript can be downloaded at the following link: https://github com/francescodestro/raav_bevs ."

"Declaration of interests R.M.K. is an inventor on patents related to recombinant AAV technology and owns equity in gene therapy-related companies. Portions of the recombinant AAV technology studied in this report are covered by United States and European patents assigned to the Secretary of the U.S. Department of Health and Human Services. A fraction of the licensing fees and royalty payments made to the National Institutes of Health is distributed to the inventors (R.M.K.) in accordance with U.S. Government and National Institutes of Health policy."

"This work was done in Cambridge, MA, USA. This work was supported by the 10.13039/100000038US Food and Drug Administration through contract 75F40121C00131."