Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic T<sub>H</sub>1 cell responses in Crohn's disease.

Authors:
Martini GR; Tikhonova E; Rosati E; DeCelie MB; Sievers LK and 32 more

Journal:
Nat Med

Publication Year: 2023

DOI:
10.1038/s41591-023-02556-5

PMCID:
PMC10579100

PMID:
37749331

Journal Information

Full Title: Nat Med

Abbreviation: Nat Med

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Molecular Biology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
5/6
83.3% Transparent
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Evidence found in paper:

"data availability raw paired-end scrna-seq fastq files from both gene expression and tcr libraries as well as processed gene expression and tcr data as feature-barcode matrix files and clonotype tables respectively have been deposited at the gene expression omnibus (accession no gse227638 ) and github under https://github com/agbacher/fungi . data availability raw paired-end scrna-seq fastq files from both gene expression and tcr libraries as well as processed gene expression and tcr data as feature-barcode matrix files and clonotype tables respectively have been deposited at the gene expression omnibus (accession no gse227638 ) and github under https://github com/agbacher/fungi ."

Evidence found in paper:

"data availability raw paired-end scrna-seq fastq files from both gene expression and tcr libraries as well as processed gene expression and tcr data as feature-barcode matrix files and clonotype tables respectively have been deposited at the gene expression omnibus (accession no gse227638 ) and github under https://github com/agbacher/fungi .; code availability all code is deposited in github under https://github com/agbacher/fungi ."

Evidence found in paper:

"Competing interests Since January 2023, E.R. has been an employee of GlaxoSmithKline. The remaining authors declare no competing interests."

Evidence found in paper:

"Funding Open access funding provided by Christian-Albrechts-Universität zu Kiel."

Protocol Registration
Open Access
Paper is freely available to read
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Tool: rtransparent

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Last Updated: Aug 05, 2025