Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology.

"Declarations Conflict of interestThe authors’ affiliations are as shown on the cover page. The authors had sole responsibility for the writing and content of the paper. The views and opinions expressed in the paper are those of the authors, and do not necessarily reflect the views or policies of the authors’ current or former employers. Conflict of interest The authors’ affiliations are as shown on the cover page. The authors had sole responsibility for the writing and content of the paper. The views and opinions expressed in the paper are those of the authors, and do not necessarily reflect the views or policies of the authors’ current or former employers."

"Funding This work was part of the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) Transformational Programme entitled ‘Development of an Integrated Approach for Chemicals Assessment’. J.D. received funding from ECETOC. M.L, was supported by CEFIC, the DK-EPA (MST-667-00205), the Land-BW (NAM-ACCEPT) and funding by the European Union’s Horizon 2020 research and innovation program under Grant agreements no 964537 (RISK-HUNT3R), no. 964518 (ToxFree) and no. 825759 (ENDpoiNTs). M.C. was supported by funding by the European Union's Horizon 2020 research and innovation program under Grant agreements no 964537 (RISK-HUNT3R). T.W.G. is partially supported by an award from the National Institutes of Health Research; Health Protection Unit in Environment Exposures and Health held with Imperial College London. Other authors contributed as part of their activities for the organization to which they are affiliated."