The impact of a second MRI and re-biopsy in patients with initial negative mpMRI-targeted and systematic biopsy for PIRADS ≥ 3 lesions.

"Declarations Conflict of interestThe authors declared that they have no conflict of interests. Ethical approvalAll included patients undergoing radical treatment provided written informed consent for surgery. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Institutional review boardInstitutional review board apply to each center due to observational and retrospective nature of the study. Conflict of interest The authors declared that they have no conflict of interests."

"Funding Open access funding provided by Università degli Studi di Padova within the CRUI-CARE Agreement. The authors thanks the University of Padua for supporting the free online version of the paper."