The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease.

"Declarations Ethics approval and consent to participateAll animal experiments were performed with the approval of the Garvan Institute and St. Vincent’s Hospital Animal Ethics Committee (protocol IDs AEC 08/20, 11/51, 14/40 and 17/28) as well as the animal ethics committee of the Florey Institute of Neuroscience and Mental Health (for ECoG recordings; protocol ID AEC 14-025) and Western Sydney University (for tissue collection from 5xFAD mice; protocol ID A13397), in accordance with National Health and Medical Research Council animal experimentation guidelines and the Australian Code of Practice for the Care and Use of Animals for Scientific Purposes (2013). Animals used in electrophysiology experiments were performed with the approval of the University of Otago Animal Ethics Committee (ET10-15). Consent for publicationConsent for publication on animals used in this study are detailed in the Material Transfer Agreements (MTA) between organizations. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by The Boyarsky Family Trust, The Howland-Rose Foundation, Douglas and Alison Battersby – Veruse Pty Ltd, David and Lynn King, John and Debbie Schaffer, Lady Fairfax Charitable Trust, Stanley and Charmaine Roth Foundation and we recognise the ISG Foundation in honour of Kylie. Funding was also provided by the NHMRC (grant 1083569). The funders had no role in the planning, writing, study analysis, decision to publish, or preparation of the manuscript."