Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure.

"the dataset supporting the conclusions of this article have been deposited at geo (gse237073 microbead injected animals gse211515 normal untreated animals) and publicly available at the date of publication.; availability of data and materials the dataset supporting the conclusions of this article have been deposited at geo (gse237073 microbead injected animals gse211515 normal untreated animals) and publicly available at the date of publication. availability of data and materials the dataset supporting the conclusions of this article have been deposited at geo (gse237073"

"Declarations Ethics approval and consent to participateAll animals were handled in accordance with the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research, and all procedures were approved by the Institutional Animal Care and Use Committee at Schepens Eye Research Institute. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work and members of the Sun lab (D.S. and A.G.M.) were supported by NIH-NEI R01 EY029268, R21 EY033487, a Research to Prevent Blindness Grant, and a NIH Core Grant for Vision Research P30EY003790. Work by the Harvard Chan Bioinformatics Core was conducted with support from Harvard Catalyst | The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health Award UL 1TR002541) and financial contributions from Harvard University and its affiliated academic healthcare centers. The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University and its affiliated centers, or the National Institutes of Health."