Time-trend treatment effect of cardiac resynchronization therapy with or without defibrillator on mortality: a systematic review and meta-analysis.

"Conflict of interest: Béla Merkely reports grants from Boston Scientific, NRDIF Hungary, National Heart Program; personal fees from Biotronik, Abbott, Astra Zeneca, Novartis, and Boehringer-Ingelheim; and grants from Medtronic outside the submitted work. Annamária Kosztin reports grants from Bolyai Research Scholarship, consulting fees from Medtronic, personal fees from Biotronic, Boehringer-Ingelheim, Boston Scientific, AstraZeneca, Bayer, and Novartis outside the submitted work, and travel fees from AstraZeneca and Novartis outside the submitted work and reports participation on a Data Safety Monitoring Board or Advisory Board with Boehringer Ingelheim and Boston Scientific outside the submitted work. She is a committee member of the Hungarian Society of Cardiology and the secretary of the Working Group on Cardiac Arrhythmias and Pacing, Hungarian Society of Cardiology outside the submitted work. All other authors declare no competing interests."

"Funding The research presented in this paper, carried out by Semmelweis University, was supported by the Ministry of Innovation and the National Research, Development and Innovation Office within the framework of the Artificial Intelligence National Laboratory Programme, project no. RRF-2.3.1–21-2022-00004 (MILAB) was implemented with support provided by the European Union. TKP2021-NVA-12 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development, and Innovation Fund, financed under the TKP2021-NVA funding scheme. Annamária Kosztin was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Boglárka Veres was supported by Semmelweis 250+ Excellence Ph.D. Scholarship (EFOP-3.6.3-VEKOP-16-2017-00009). Sara Gharehdaghi was supported by National Research, Development, and Innovation Fund of Hungary financed under UNKP-22-3-I funding scheme."

"We reported our systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (, ). The review protocol was registered on the PROSPERO International Prospective Register of Systematic Reviews (CRD42021281869). We did not deviate from the protocol."