A virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in non-human primates.

"Competing interests B.C. has an equity stake in Metaphore Biotechnologies. A.F. is currently an employee of Moderna, Inc. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"This research was funded by NIH grant R01HL131696, by the Intramural Research Program of NHLBI, and by an award from the National Center for Advancing Translational Sciences, National Institutes of Health under grant number UL1TR001449, and award P51OD011107 from the Office of Research Infrastructure Program, Office of The Director, National Institutes of Health to the California National Primate Research Center. We thank the staff of CNPRC Colony Management and Research Services, Clinical Laboratories, Anatomic and Clinical Pathology and Veterinary staff for their expert technical assistance. We also thank Alexandra Francian for her valuable comments on the manuscript."