Integration of single-nuclei RNA-sequencing, spatial transcriptomics and histochemistry defines the complex microenvironment of NF1-associated plexiform neurofibromas.

"availability of data and materials snrna-seq and st data have been deposited in the national center for biotechnology information gene expression omnibus (geo) database and are publicly accessible through geo accession number gse232766 ( https://www ncbi nlm nih gov/geo/query/acc cgi? availability of data and materials snrna-seq and st data have been deposited in the national center for biotechnology information gene expression omnibus (geo) database and are publicly accessible through geo accession number gse232766"

"Declarations Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding Funding for this project was provided by the Cancer League of Colorado. Additional support was provided by the Morgan Adams Foundation. The University of Colorado Denver Genomics and Microarray and Histology Resources are supported by the National Institutes of Health/National Cancer Institute University of Colorado Cancer Center Grant (P30CA046934)."