Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model.

Authors:
Shing K; Sapp E; Boudi A; Liu S; Seeley C and 3 more

Journal:
Neurobiol Dis

Publication Year: 2023

DOI:
10.1016/j.nbd.2023.106313

PMCID:
PMC10731584

PMID:
37777020

Journal Information

Full Title: Neurobiol Dis

Abbreviation: Neurobiol Dis

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Neurology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
3/6
50.0% Transparent
Transparency Indicators
Click on green indicators to view evidence text
Core Indicators
Evidence found in paper:

"rna-sequencing data analyzed is available at gene expression omnibus (geo) accession number gse156236. data availability all datasets generated are included in this article and can be found in supplemental files2 - 6 . rna-sequencing data analyzed is available at gene expression omnibus (geo) accession number gse156236"

Code Sharing
COI Disclosure
Evidence found in paper:

"Funding This work was funded by CHDI Foundation, Inc., a nonprofit biomedical research organization exclusively dedicated to developing therapeutics that will substantially improve the lives of HD-affected individuals, the Dake Family Fund to MD and KBK-G, and NIH 1S10RR023594S10 to MD."

Protocol Registration
Open Access
Paper is freely available to read
Additional Indicators
Replication
Novelty Statement
Assessment Info

Tool: rtransparent

OST Version: N/A

Last Updated: Aug 05, 2025