Resistance to PRMT5-targeted therapy in mantle cell lymphoma.

Authors:
Long ME; Koirala S; Sloan S; Brown-Burke F; Weigel C and 19 more

Journal:
Blood Adv

Publication Year: 2024

DOI:
10.1182/bloodadvances.2023010554

PMCID:
PMC10787272

PMID:
37782774

Journal Information

Full Title: Blood Adv

Abbreviation: Blood Adv

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Hematology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
5/6
83.3% Transparent
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Evidence found in paper:

"whole exome sequencing and rna-seq data are deposited in the gene expression omnibus database (accession number gse240726). processed experimental data are available at figshare (private link for reviewer access https://figshare com/s/7a755a5ad0015e643c93 ) and the code is available at https://github com/blaserlab/baiocchi_long . processed experimental data are available at figshare (private link for reviewer access https://figshare com/s/7a755a5ad0015e643c93 ) and the code is available at https://github com/blaserlab/baiocchi_long ."

Evidence found in paper:

"processed experimental data are available at figshare (private link for reviewer access https://figshare com/s/7a755a5ad0015e643c93 ) and the code is available at https://github com/blaserlab/baiocchi_long ."

Evidence found in paper:

"Conflict-of-interest disclosure: P.S. and K.V. report employment with Prelude Therapeutics. K.V. and P.S. report stock holdings in Prelude Therapeutics. R.B. reports research support from Prelude Therapeutics. The remaining authors declare no competing financial interests."

Evidence found in paper:

"M.E.L. was supported by The Ohio State University Comparative Biomedical Sciences Graduate Program, the Genentech Veterinary Pathology Fellowship, and the F-32: Ruth L. Kirschstein Postdoctoral Individual NRSA (1F32CA265099-01) during this work. Histology, immunohistochemistry, and pathology support services were provided by the Comparative Pathology & Digital Imaging Shared Resource, Department of Veterinary Biosciences, and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH, and supported in part by grant P30 CA16058, National Institutes of Health, 10.13039/100000054National Cancer Institute, Bethesda, MD. This work was also supported by The 10.13039/100006928Ohio State University Genomics Shared Resource and Comprehensive Cancer Center, Weill Cornell Medicine Genomics Core Facility, the National Cancer Institute Cancer Center Support Grant (5P01CA214274-03) (R. B.), the 10.13039/100005189Leukemia and Lymphoma Society (longitudinal functional genomics in mantle cell lymphoma therapy and drug resistance) (R. B.), and The James Comprehensive Cancer Center at The Ohio State University (NCIP30 CA016058)."

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Open Access
Paper is freely available to read
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Last Updated: Aug 05, 2025