Integrative bioinformatics analysis and experimental validation of key biomarkers for risk stratification in primary biliary cholangitis.

"series matrix files and corresponding clinical information of two datasets (gse79850 and gse119600) were downloaded from the geo database ( https://www ncbi nlm nih gov/geo/ ) gse79850 was based on the gpl 19965 annotation platform which included 16 pbc liver tissue samples and 8 control samples.; availability of data and materials the data in this study that support the findings are available in the geo database ( https://www ncbi nlm nih gov/geo/ ) with the following data accession number(s): gse79850 and gse119600. availability of data and materials the data in this study that support the findings are available in the geo database ( https://www ncbi nlm nih gov/geo/ ) with the following data accession number(s): gse79850"

"Declarations Ethics approval and consent to participateThe study conformed to the provisions of the Declaration of Helsinki (as revised in 2013). The research was approved by the Institutional Research Ethics Committees of the Xijing Hospital (KY20173316-1). Written informed consent was obtained from all patients. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding The study was funded by National Natural Science Foundation of China (No. 81820108005, 82270551 & 81900502), National Key Research and Development Program of China (No. 2020YFA0710803 & 2017YFA0105704), and Key Research and Development Projects of Shaanxi Province (No. 2021ZDLSF02-07, 2022ZDLSF03-03, 2023ZDLSF-33 & 2023KJXX-026)."