Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas.

"availability of data and materials the infinium methylationepic data from all the pooled samples generated and analyzed during this study have been deposited in the ncbi gene expression omnibus (geo) ( www ncbi nlm nih gov/geo ) and are accessible through geo series accession number gse186381 [ https://www ncbi nlm nih gov/geo/query/acc cgi?"

"Declarations Ethics approval and consent to participateWritten informed consent was obtained from all patients with approval by the Ethics Committee for Clinical Research of Galicia (2018/008). The study was conducted according to the clinical and ethical principles of the Spanish Government and the Declaration of Helsinki. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work received funding from Plan Nacional I+D+I 2015–2018 (Acción Estratégica en Salud) Instituto de Salud Carlos III (Spain)-FEDER (PI15/02007) and Fundación Científica de la Asociación Española contra el Cáncer (GCB13131592CAST), and support from Centro Singular de Investigación de Galicia (Consellería de Cultura, Educación e Ordenación Universitaria) (ED431G/02, Xunta de Galicia and FEDER-European Union). María Gallardo-Gómez was supported by a predoctoral fellowship from Ministerio de Educación, Cultura y Deporte (Spanish Government) (FPU15/02350)."