Adolescents at risk for depression show increased white matter microstructure with age across diffuse areas of the brain.

"Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"We would like to thank Feroze Mohammed for assistance at the Jefferson MRI center, Huiling Peng for advice on diffusion imaging, and all of the individuals involved in data collection, clinical interviews, and data cleaning, including: Emily Hockenberry, Christina Cerra, Evan Burdette, Subhashini Madhavan, Darien Aunapu, Karina Guerra-Guzman, Kristina Dale, Christine Lederer, Julia Case, Samantha Birk, Rebekah Mennies, Johanna Nielsen, and Zuzanna Wojcieszak. This work was supported by the 10.13039/100000002National Institutes of Health grants R01 MH107495 (Olino), F32 MH127948–01A1 (Sullivan-Toole), and R01HD099165; R01MH091113 (Olson). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health. Additionally, this research includes calculations carried out on HPC resources supported by the 10.13039/100000001National Science Foundation through major research instrumentation grant number 1625061 and by the US Army Research Laboratory under contract number W911NF-16–2-0189."