Improvement of composite kidney outcomes by AKI care bundles: a systematic review and meta-analysis.

"Declarations Ethical approval and consent to participateNot applicable. Consent for publicationNot applicable. Competing interestsAll authors declare no competing interest. Competing interests All authors declare no competing interest."

"Funding The research did not receive any specific grant from funding agencies in public, commercial, or not-for-profit sectors."

"This systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (Additional file : Table S1 and S2). The protocol was registered within the International Platform of Registered Systemic Review and Meta-analysis Protocols (INPLASY202370043). We performed a comprehensive literature search using PubMed, EMBASE, and Cochrane Library to identify all studies published since 2012 that had included AKI care bundles. The following key terms were included: “acute kidney injury”, “acute kidney failure”, “acute renal failure”, “urinary biomarker”, “neutrophil gelatinase associated lipocalin”, “NGAL”, “tissue inhibitor of metalloproteinase 2”, “tissue inhibitor of matrix metalloproteinase 2”, “TIMP-2·IGFBP7”, “care bundle”, “renal replacement therapy”, “mortality”, “randomized controlled trial”, “cohort analysis”, and “cohort study”."