Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders.

"availability of data and materials pseudonymized data are available from the authors on reasonable request. declarations ethics approval and consent to participate the study was approved by the institutional review board of tud (bo-ek-444092021"

"Declarations Ethics approval and consent to participateThe study was approved by the institutional review board of TUD (BO-EK-444092021), and written informed consent was obtained from all participants before inclusion in the study. Consent for publicationNot applicable. Competing interestsSB, MR, JS, TH and PP report no competing interests. TG received speakers’ honoraria by Lundbeck, UCB, and Desitin. He is member of advisory boards for Bayer, Eli Lilly and Ono Pharmaceuticals. KB reports grants from the German Research Foundation (DFG), German Parkinsons Disease Association (dPV), Michael J. Fox Foundation, outside the submitted work. She received travel grants from the Movement Disorders Society and speaker honoraria from Abbvie, Lundbeck, UCB and Zambon and was invited to Advisory Boards for F. Hoffmann La Roche Ltd. BF reports grants from the German Research Foundation (DFG) and speaker honoraria from AbbVie, Stadapharm, Desitin, Zambon and Bial. Competing interests SB, MR, JS, TH and PP report no competing interests. TG received speakers’ honoraria by Lundbeck, UCB, and Desitin. He is member of advisory boards for Bayer, Eli Lilly and Ono Pharmaceuticals. KB reports grants from the German Research Foundation (DFG), German Parkinsons Disease Association (dPV), Michael J. Fox Foundation, outside the submitted work. She received travel grants from the Movement Disorders Society and speaker honoraria from Abbvie, Lundbeck, UCB and Zambon and was invited to Advisory Boards for F. Hoffmann La Roche Ltd. BF reports grants from the German Research Foundation (DFG) and speaker honoraria from AbbVie, Stadapharm, Desitin, Zambon and Bial."

"Funding Open Access funding enabled and organized by Projekt DEAL. SB, MR, JS, TH, BF report no external funding related to the conduct of this study. TG reports Funding by the Michael J. Fox Foundation and the German Centre for Neurodegenerative Diseases (DZNE) in relation to the study. PP reports grants from the Ministero della Salute (Ricerca Corrente) and the Regione Emilia Romagna (Fin-RER 2020) related to the conduct of this study. KB reports grants from German Federal Ministry of Education and Research (BMBF, part of ERACoSysMed2) and German Centre for Neurodegenerative Diseases (DZNE) related to the conduct of this study."