Triptan non-response in specialized headache care: cross-sectional data from the DMKG Headache Registry.

"Declarations Ethics approval and consent to participateThe present study has been approved by the ethics committee of the Ludwig-Maximilians-University Munich (leading ethics committee, 20-004), and by the responsible ethics committee of every participating headache center. Informed consent was obtained from every subject before participation. Consent for publicationNot applicable. Competing interestsRR has received travel grants and/or honoraria for lectures or advisory boards from Allergan/AbbVie, Hormosan, Lilly, Lundbeck, Novartis and Teva.GG has received honoraria from Lilly, Novartis Pharma, Teva, Lundbeck, and research grants from Novartis Pharma during the last 3 years. She does not hold any stocks of pharmaceutical companies.TD has received honoraria for consulting and lectures from Hormosan Pharma, Novartis Pharma, and TEVA.TF received honoraria for advisory boards from Novartis, Teva and Lundbeck and honoraria for lectures from Novartis, Teva, Lilly, Bayer and UCS.SF received honoraria from Allergan/AbbVie, Hormosan, Eli Lilly, Lundbeck, Novartis, Sanofi and Teva. She served on Advisory Boards for Hormosan, Eli Lilly, Lundbeck, Novartis, Sanofi and Teva.CG has received honoraria for consulting and lectures within the past 3 years from Abbvie, Lilly, Novartis Pharma, Hormosan Pharma, Grünenthal, Sanofi-Aventis, Lundbeck, Perfood, Reckitt and TEVA. His research is supported by a grant of the German Research Foundation (DFG). He does not hold any stocks of pharmaceutical companies. He is honorary secretary of the German Migraine and Headache Society.TK has received travel grants and/or honoraria from Allergan/AbbVie, Hormosan, Lilly, Novartis and Teva.LN received honoraria for lectures and advisory boards vrom Hormosan, Lilly, Novartis, Teva, AbbVie/Allergan.VR received the Soyka award as a research grant from Novartis.AS has received honoraria for adboards and educational talks from Allergan/AbbVie, Allergosan, Lilly, Lundbeck, Novartis, Sanofi, Teva.JS declares no conflict of interest.TPJ has received honoraria from Allergan/AbbVie, Grünenthal, Hormosan, Lilly, Lundbeck, Novartis, Sanofi and Teva. He served on Advisory Boards and/or consulted for Allergan/AbbVie, Hormosan, Lilly, Lundbeck, Novartis and Teva.TPJ has received honoraria from Allergan/AbbVie, Grünenthal, Hormosan, Lilly, Lundbeck, Novartis, Sanofi and Teva. He served on Advisory Boards and/or consulted for Allergan/AbbVie, Hormosan, Lilly, Lundbeck, Novartis and Teva. Competing interests RR has received travel grants and/or honoraria for lectures or advisory boards from Allergan/AbbVie, Hormosan, Lilly, Lundbeck, Novartis and Teva. GG has received honoraria from Lilly, Novartis Pharma, Teva, Lundbeck, and research grants from Novartis Pharma during the last 3 years. She does not hold any stocks of pharmaceutical companies. TD has received honoraria for consulting and lectures from Hormosan Pharma, Novartis Pharma, and TEVA. TF received honoraria for advisory boards from Novartis, Teva and Lundbeck and honoraria for lectures from Novartis, Teva, Lilly, Bayer and UCS. SF received honoraria from Allergan/AbbVie, Hormosan, Eli Lilly, Lundbeck, Novartis, Sanofi and Teva. She served on Advisory Boards for Hormosan, Eli Lilly, Lundbeck, Novartis, Sanofi and Teva. CG has received honoraria for consulting and lectures within the past 3 years from Abbvie, Lilly, Novartis Pharma, Hormosan Pharma, Grünenthal, Sanofi-Aventis, Lundbeck, Perfood, Reckitt and TEVA. His research is supported by a grant of the German Research Foundation (DFG). He does not hold any stocks of pharmaceutical companies. He is honorary secretary of the German Migraine and Headache Society. TK has received travel grants and/or honoraria from Allergan/AbbVie, Hormosan, Lilly, Novartis and Teva. LN received honoraria for lectures and advisory boards vrom Hormosan, Lilly, Novartis, Teva, AbbVie/Allergan. VR received the Soyka award as a research grant from Novartis. AS has received honoraria for adboards and educational talks from Allergan/AbbVie, Allergosan, Lilly, Lundbeck, Novartis, Sanofi, Teva. JS declares no conflict of interest. TPJ has received honoraria from Allergan/AbbVie, Grünenthal, Hormosan, Lilly, Lundbeck, Novartis, Sanofi and Teva. He served on Advisory Boards and/or consulted for Allergan/AbbVie, Hormosan, Lilly, Lundbeck, Novartis and Teva.TPJ has received honoraria from Allergan/AbbVie, Grünenthal, Hormosan, Lilly, Lundbeck, Novartis, Sanofi and Teva. He served on Advisory Boards and/or consulted for Allergan/AbbVie, Hormosan, Lilly, Lundbeck, Novartis and Teva."

"Funding Open Access funding enabled and organized by Projekt DEAL. The DMKG Headache Registry is funded by the German Migraine and Headache Society and by unrestricted grants from companies with an interest in headache research (up to the time of submission of this work, Lilly, Teva, Novartis, and Lundbeck have made contributions). Supporting companies were given the opportunity to comment on the research protocol, and their comments were considered where judged to be scientifically relevant. Apart from that, supporting companies did not influence the study design. Pfizer supported part of a previous version of the present analysis. None of the companies influenced data collection, analysis, interpretation or writing of the manuscript."

"Trial registration The DMKG Headache Registry is registered with the German Clinical Trials Register (DRKS 00021081)."